Gastroenterology - Penthrox for Pain Relief

What is Penthrox?

Penthrox is a medication used to relieve pain during Endoscopic procedures. It contains a substance called methoxyflurane, which is inhaled through a special device.

How does Penthrox work?

When inhaled, Penthrox numbs the nerves that transmit pain signals to the brain. This helps to reduce the sensation of pain quickly and effectively.

When is Penthrox used?

Penthrox is an off-license medication used for outpatient procedures in the United Kingdom and other parts of the world.

How is Penthrox administered?

Penthrox is inhaled through a hand-held device called a Penthrox inhaler. The healthcare provider will instruct you on how to use it correctly. It’s important to follow their instructions carefully.

What are the benefits of using Penthrox?

• Fast pain relief: Penthrox starts working quickly to relieve pain
• Ease to use: The inhaler is portable and straightforward to use
• Minimal side effects: Penthrox is generally well-tolerated when used as directed

What are the possible side effects?

Like all medications, Penthrox can cause side effects, although not everyone will experience them.

Common side effects may include:

• Dizziness or light-headedness
• Nausea or vomiting
• Headache
• Sweating
• Feeling sleepy or tired

If you experience any severe or persistent side effects, inform your healthcare provider immediately.

Important safety information

• Avoid driving if you experience dizziness or drowsiness
• Inform your healthcare provider: Let your healthcare provider know about any other medications you are taking, as well as any medical conditions you have, before using Penthrox.

Who should not use Penthrox?

Penthrox may not be suitable for everyone.

You should not use Penthrox if:

• You are allergic to methoxyflurane or any inhalation anaesthetics
• You have a history or family history of malignant hyperthermia
• You have previously experienced liver damage from methoxyflurane or other inhalation anaesthetics
• You have severe liver or kidney problems

Penthrox is an effective medication for short-term pain relief in various situations.

It provides fast relief with minimal side effects when used as directed.

If you have any questions or concerns about using Penthrox, consult your healthcare provider for further guidance. 

You can get further information from:

Electronic Medicines Compendium (EMC)
https://www.medicines.org.uk/emc/files/pil.1939.pdf

Penthrox:
https://penthrox.co.uk/patients/

Further Information:

We endeavour to always provide an excellent service, but should you have any concerns please, in the first instance, raise these with the Matron, Senior Nurse or Manager on duty.

If they cannot resolve your concern, please contact our Patient Advice & Liaison Service on 0161 778 5665 or email: pals@nca.nhs.uk

If you remain concerned, the team can also advise upon how to make a formal complaint.